Phenotypes Associated with This Genotype

Genotype
MGI:3846579

• Allelic Composition: Fat4^tm1.1Hmc/Fat4^tm1.1Hmc; Fjx1^tm1Awp/Fjx1^tm1Awp
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:138247 )

• fewer than expected mice are found at P0

renal/urinary system

kidney cyst ( J:138247 )

• increase in the severity of cystic tubules compared to mice homozygous for Fat4^tm1.1Hmc alone

enlarged kidney ( J:138247 )

• in some cases cysts are so large that overall kidney size is dramatically increased

hydronephrosis ( J:138247 )

• associated with enlarged kidneys

duplex kidney ( J:138247 )

• associated with enlarged kidneys

double ureter ( J:138247 )

• double ureter, associated with enlarged kidneys

growth/size/body

kidney cyst ( J:138247 )

• increase in the severity of cystic tubules compared to mice homozygous for Fat4^tm1.1Hmc alone

enlarged kidney ( J:138247 )

• in some cases cysts are so large that overall kidney size is dramatically increased