Phenotypes Associated with This Genotype

Genotype
MGI:3846226

• Allelic Composition: Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell apoptosis ( J:148490 )

• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA

increased T-helper 2 cell number ( J:148490 )

• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are moderately enhanced compared to wild-type controls

abnormal macrophage morphology ( J:148490 )

• mice have enhanced numbers of alternatively activated macrophages in the lung

• numbers of alternatively activated macrophages are even more enhanced in response to OVA sensitization and challenge

cellular

decreased apoptosis ( J:148490 )

• apoptosis rates of immune cells in the lung after challenge with OVA are reduced compared to controls

decreased T cell apoptosis ( J:148490 )

• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA

hematopoietic system

decreased T cell apoptosis ( J:148490 )

• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA

increased T-helper 2 cell number ( J:148490 )

• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are moderately enhanced compared to wild-type controls

abnormal macrophage morphology ( J:148490 )

• mice have enhanced numbers of alternatively activated macrophages in the lung

• numbers of alternatively activated macrophages are even more enhanced in response to OVA sensitization and challenge