Phenotypes Associated with This Genotype

Genotype
MGI:3845825

• Allelic Composition: Tg(Ckm-Ppargc1a)31Brsp/0
• Genetic Background: C57BL/6-Tg(Ckm-Ppargc1a)31Brsp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:78333 )

• most muscles in transgenic animals display a red color characteristic of oxidative muscle; in contrast, control muscles are paler in appearance

abnormal muscle physiology ( J:78333 )

• muscles in mutant animals are able to sustain a longer duration of continuous contraction; isolated extensor digitorum longus (EDL) muscles show much greater fatigue resistance compared to control muscle

• muscle fiber diameter loss in response to denervation and fasting is less severe in transgenic animals when compared to controls

behavior/neurological

abnormal depression-related behavior ( J:213551 )

• following 5 weeks of a chronic mild stress (CMS) protocol, transgenic mice do not exhibit the increased immobility in forced swim test or decreased sucrose consumption that is observed in wild-type mice

• however, transgenic mice exhibit decreases in body weight similar to wild-type