Phenotypes Associated with This Genotype

Genotype
MGI:3845774

• Allelic Composition: Thim^{Tg(Myh6-TGFB1)1Ljf}/Thim⁺
• Genetic Background: involves: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:59903 )

• 59.9% of mice die by 20 weeks of age due to complications from thymoma

• mortality rates are higher in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)

• only 5 of 82 mice lived longer than 60 weeks

neoplasm

increased T cell derived lymphoma incidence ( J:59903 )

• thymomas develop with a high penentrance in this transgenic line but not other lines

• thymomas do not express the transgene

• tumor progression is more aggressive in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)

• thymomas are of epithelial origin with desmosomes, cilia, and tonofibrils all evident within the tumor cells

cardiovascular system

abnormal vena cava morphology ( J:59903 )

• the vena cava is often ruptured by thymomas leading to death of the mouse

respiratory system

respiratory distress ( J:59903 )

• mice display respiratory distress as they age

liver/biliary system

abnormal liver morphology ( J:59903 )

• all mice exhibit liver congestion

vision/eye

exophthalmos ( J:59903 )

• all mice exhibit this

homeostasis/metabolism

extremity edema ( J:59903 )

• mice develop edema as they age

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:59903 )

• thymomas develop with a high penentrance in this transgenic line but not other lines

• thymomas do not express the transgene

• tumor progression is more aggressive in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)

• thymomas are of epithelial origin with desmosomes, cilia, and tonofibrils all evident within the tumor cells

hematopoietic system

increased T cell derived lymphoma incidence ( J:59903 )

• thymomas develop with a high penentrance in this transgenic line but not other lines

• thymomas do not express the transgene

• tumor progression is more aggressive in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)

• thymomas are of epithelial origin with desmosomes, cilia, and tonofibrils all evident within the tumor cells

immune system

increased T cell derived lymphoma incidence ( J:59903 )

• thymomas develop with a high penentrance in this transgenic line but not other lines

• thymomas do not express the transgene

• tumor progression is more aggressive in females (73.9% mortality at 20 weeks of age) than males (41.7% mortality)

• thymomas are of epithelial origin with desmosomes, cilia, and tonofibrils all evident within the tumor cells