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Phenotypes Associated with This Genotype
Genotype
MGI:3845546
Allelic
Composition		 Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Otx2tm1Pas/Otx2tm2Asim
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Otx2tm1Pas mutation (2 available); any Otx2 mutation (51 available)
Otx2tm2Asim mutation (1 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:72725 )
N
• mice are viable at E10.5

nervous system
abnormal brain development ( J:72725 )
• brain development is compromised
• however, mice exhibit rescue of the anterior defects observed in Otx2tm1(OTX1)Asim/Otx2tm1Pas heterozygotes

cardiovascular system
cardiovascular system phenotype ( J:72725 )
N
• heart development is normal

growth/size/body
abnormal head development ( J:72725 )
• head development is compromised

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory