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Phenotypes Associated with This Genotype
Genotype
MGI:3845545
Allelic
Composition
Gbx2tm1.1Mrt/Gbx2tm1.1Mrt
Otx2tm1(OTX1)Asim/Otx2tm1(OTX1)Asim
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Otx2tm1(OTX1)Asim mutation (1 available); any Otx2 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although present at E9.5, no mice are detected at E10 to E10.5

nervous system
• at E9.7, mice fail to exhibit regionalization of the anterior neural plate unlike wild-type mice
• at E9.7, the distance between the otic vesicle and the rostral tip of the embryo is greater than in wild-type embryos
• at E9.7, the anterior neuroectoderm is abnormal
• at E9.7, telencephalic vesicles are not recognizable
• at E9.7, the isthmic constriction is not recognizable

cardiovascular system
• at E9.7

embryo
• at E9.7, mice fail to exhibit regionalization of the anterior neural plate unlike wild-type mice
• at E9.7, the distance between the otic vesicle and the rostral tip of the embryo is greater than in wild-type embryos
• at E9.7, the anterior neuroectoderm is abnormal

craniofacial

growth/size/body

respiratory system

taste/olfaction

vision/eye
• at E9.7, the optic placodes are absent
• at E9.7, optic vesicles are not recognizable


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory