mortality/aging
• although present at E9.5, no mice are detected at E10 to E10.5
|
nervous system
• at E9.7, mice fail to exhibit regionalization of the anterior neural plate unlike wild-type mice
• at E9.7, the distance between the otic vesicle and the rostral tip of the embryo is greater than in wild-type embryos
|
• at E9.7, the anterior neuroectoderm is abnormal
|
• at E9.7, telencephalic vesicles are not recognizable
|
• at E9.7, the isthmic constriction is not recognizable
|
exencephaly
(
J:72725
)
cardiovascular system
• at E9.7
|
dilated heart
(
J:72725
)
• at E9.7
|
embryo
• at E9.7
|
• at E9.7, mice fail to exhibit regionalization of the anterior neural plate unlike wild-type mice
• at E9.7, the distance between the otic vesicle and the rostral tip of the embryo is greater than in wild-type embryos
|
• at E9.7, the anterior neuroectoderm is abnormal
|
craniofacial
• at E9.7
|
• at E9.7
|
growth/size/body
respiratory system
• at E9.7
|
taste/olfaction
• at E9.7
|
vision/eye
• at E9.7, the optic placodes are absent
|
• at E9.7, optic vesicles are not recognizable
|