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Phenotypes Associated with This Genotype
Genotype
MGI:3845353
Allelic
Composition		 Prkar1atm2Gsm/Prkar1atm2Gsm
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm2Gsm mutation (1 available); any Prkar1a mutation (19 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:147785 )
• following stimulation with LPS and LPS plus IL4, splenic B cells exhibit impaired class switch recombination compared with wild-type cells
• however, stimulated B cell proliferation is normal

hematopoietic system
abnormal class switch recombination ( J:147785 )
• following stimulation with LPS and LPS plus IL4, splenic B cells exhibit impaired class switch recombination compared with wild-type cells
• however, stimulated B cell proliferation is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory