Phenotypes Associated with This Genotype

Genotype
MGI:3845244

• Allelic Composition: Pax1^tm1Neu/Pax1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal sternum morphology ( J:49339 )

• 88% of mice exhibit abnormalities in the first two cervical vertebrae, in the lumbar region, and/or the sternum

• 34% of mice exhibit ossification of intersternebra 5

abnormal vertebrae morphology ( J:49339 )

• 88% of mice exhibit abnormalities in the first two cervical vertebrae, in the lumbar region, and/or the sternum

abnormal cervical atlas morphology ( J:49339 )

• 63% of mice exhibit ventral fusion of the axis to the arcus of the atlas by cartilaginous bridge

abnormal ventral tubercle of atlas morphology ( J:49339 )

• the ventral tubercle of the arcus is enlarged

abnormal lumbar vertebrae morphology ( J:49339 )

• 44% of mice exhibit abnormalities in the lumbar region

• in most cases, L4 displays dual ossification centers unlike in wild-type mice

• in 3 of 32 mice, the pedicles fuse to one of the twin ossification centers and costal processes of the affected vertebrae are missing unlike in wild-type mice