Phenotypes Associated with This Genotype

Genotype
MGI:3845229

• Allelic Composition: Cd34^tm1Lal/Cd34^tm1Lal
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:30621 )

• mean CFU isolated from yolk sacs is about half of controls

• high proliferative potential colony-forming cells is decreased by almost 70% in the bone marrow and 85% in the spleen

abnormal common myeloid progenitor cell morphology ( J:30621 )

• mean CFU isolated from fetal liver is much less than controls

• CFU-GM is reduced by about 66% in the bone marrow and CFU-GEMM by 73%

• CFU-GM is reduced by 87% in the bone marrow and spleen

• CFU-GEMM is reduced by 78% in the blood

decreased erythroid progenitor cell number ( J:30621 )

• mean BFU-E isolated from fetal liver is significantly less than controls

• BFU-E is reduced by 54% in the bone marrow and 78% in the spleen

decreased splenocyte number ( J:30621 )

• splenocyte number is 49% that of control

immune system

decreased splenocyte number ( J:30621 )

• splenocyte number is 49% that of control