Phenotypes Associated with This Genotype

Genotype
MGI:3845009

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Tg(Tcra,Tcrb)HRCAll/0
• Genetic Background: B6.Cg-Rag1^tm1Mom Tg(Tcra,Tcrb)HRCAll

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:131347 )

• mature peripheral T cells are selected to the CD8+ lineage

• however, mice do not exhibit clonal deletion or co-receptor downregulation in the thymus or activation in the periphery

abnormal T cell subpopulation ratio ( J:131347 )

• mature peripheral T cells are selected to the CD8+ lineage

absent CD4-positive, alpha-beta T cells ( J:131347 )

increased CD8-positive, alpha-beta T cell number ( J:131347 )

hematopoietic system

abnormal T cell differentiation ( J:131347 )

• mature peripheral T cells are selected to the CD8+ lineage

• however, mice do not exhibit clonal deletion or co-receptor downregulation in the thymus or activation in the periphery

abnormal T cell subpopulation ratio ( J:131347 )

• mature peripheral T cells are selected to the CD8+ lineage

absent CD4-positive, alpha-beta T cells ( J:131347 )

increased CD8-positive, alpha-beta T cell number ( J:131347 )