Phenotypes Associated with This Genotype

Genotype
MGI:3844893

• Allelic Composition: H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:67941 )

• peripheral CD4⁺ T cell numbers are reduced more than 10-fold

decreased single-positive T cell number ( J:67941 )

• CD4 single-positive thymocyte numbers are decreased to 2.1% of thymocytes compared to 7.6% in wild-type controls

decreased IgG1 level ( J:67941 )

• mice fail to produce measurable antigen specific IgG1 levels in response to T cell dependent antigens even after two doses

decreased IgM level ( J:67941 )

• mice fail to produce measurable antigen specific IgM levels in response to T cell dependent antigens

abnormal level of surface class II molecules ( J:67941 )

• MHC II complex is not expressed on the surface of cells

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:67941 )

• peripheral CD4⁺ T cell numbers are reduced more than 10-fold

decreased single-positive T cell number ( J:67941 )

• CD4 single-positive thymocyte numbers are decreased to 2.1% of thymocytes compared to 7.6% in wild-type controls

decreased IgG1 level ( J:67941 )

• mice fail to produce measurable antigen specific IgG1 levels in response to T cell dependent antigens even after two doses

decreased IgM level ( J:67941 )

• mice fail to produce measurable antigen specific IgM levels in response to T cell dependent antigens