Phenotypes Associated with This Genotype

Genotype
MGI:3844865

• Allelic Composition: Tg(Prdx6)153Pgn/0
• Genetic Background: C57BL/6-Tg(Prdx6)153Pgn/Pgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:120623 )

• mice exposed to hyperoxic conditions exhibit delayed mortality compared to similarly treated wild-type mice

immune system

abnormal macrophage physiology ( J:86528 )

• exhibit reduced hydrogen peroxide compared to in similarly treated wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:86528 )

N • mice fed a high fat diet, exhibit normal HDL concentrations

decreased susceptibility to injury ( J:120623 )

• under hyperoxic conditions, mice exhibit decreased response; less severe lung injury, including reduced increase in lung wet:dry weight ratio, necrosis of bronchiolar epithelium, perivascular and alveolar edema, and number of inflammatory cells in the airspaces; and delayed mortality compared with wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:86528 )

N • mice fed a high fat diet develop normal atherosclerotic lesions

hematopoietic system

abnormal macrophage physiology ( J:86528 )

• exhibit reduced hydrogen peroxide compared to in similarly treated wild-type mice