About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3844820
Allelic
Composition
Mertktm1Gkm/Mertktm1Gkm
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background
NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mertktm1Gkm mutation (2 available); any Mertk mutation (66 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the frequency of double positive T cell apoptosis in thymic lobes is increased compared to in similarly treated heterozygous mice
• fetal thymic organ cultures treated with BDC2.5 produce fewer double positive thymocytes than similarly treated heterozygous cells
• fetal thymic organ cultures treated with BDC2.5 produce more CD8+ single positive thymocytes than similarly treated heterozygous cells

hematopoietic system
• the frequency of double positive T cell apoptosis in thymic lobes is increased compared to in similarly treated heterozygous mice
• fetal thymic organ cultures treated with BDC2.5 produce fewer double positive thymocytes than similarly treated heterozygous cells
• fetal thymic organ cultures treated with BDC2.5 produce more CD8+ single positive thymocytes than similarly treated heterozygous cells

cellular
• the frequency of double positive T cell apoptosis in thymic lobes is increased compared to in similarly treated heterozygous mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
01/06/2026
MGI 6.24
The Jackson Laboratory