Phenotypes Associated with This Genotype

Genotype
MGI:3844714

• Allelic Composition: Ptgs2^tm1Gaf/Ptgs2^tm1Gaf; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/?
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:148331 )

• hypertrophy of cardiomyocytes occurs after 6 weeks of aortic banding to mice that have had cre expression induced

dilated heart left ventricle ( J:148331 )

• left ventricular end systolic volume is increased after cre induction from 0.017 cm³/g to 0.021 cm³/g

decreased ventricle muscle contractility ( J:148331 )

• after cre induction, the left ventricular ejection fraction is depressed from 0.65 cm³/g to 0.60 cm³/g

decreased heart rate ( J:148331 )

• heart rate is depressed after cre induction from 443 bpm to 441 bpm

ventricular tachycardia ( J:148331 )

• male mice with cre induction and intracardiac electrical stimulation have more ventricular tachycardia episodes than controls (17 vs. 3)

• duration of these episodes are also about 3-fold longer than controls

growth/size/body

weight loss ( J:148331 )

• mice in which cre expression is induced have more weight loss than controls in response to exercise

homeostasis/metabolism

impaired exercise endurance ( J:148331 )

• mice with cre expression have a reduced exercise capacity

muscle

increased myocardial fiber size ( J:148331 )

• hypertrophy of cardiomyocytes occurs after 6 weeks of aortic banding to mice that have had cre expression induced

decreased ventricle muscle contractility ( J:148331 )

• after cre induction, the left ventricular ejection fraction is depressed from 0.65 cm³/g to 0.60 cm³/g

behavior/neurological

impaired exercise endurance ( J:148331 )

• mice with cre expression have a reduced exercise capacity