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Phenotypes Associated with This Genotype
Genotype
MGI:3844697
Allelic
Composition		 Prf1tm1Sdz/Prf1tm1Sdz
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 NOD.Cg-Rag1tm1Mom Prf1tm1Sdz/SzJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1tm1Sdz mutation (17 available); any Prf1 mutation (54 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:91764 )
• streptozotocin-treated mice exhibit increased serum glucose levels that can be restored transiently to euglycemia by transplanting islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice
• 70% of streptozotocin-treated mice transplanted with islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice and HLA-A2 negative human peripheral blood mononuclear cells exhibit increased glucose serum levels
• however, all of streptozotocin-treated mice transplanted with islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice and HLA-A2 positive human peripheral blood mononuclear cells exhibit euglycemia

immune system
abnormal response to transplant ( J:91764 )
• streptozotocin-treated mice transplanted with islet cells from Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl transgenic mice and HLA-A2 negative human peripheral blood mononuclear cells exhibit destruction of engrafted islet cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory