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Phenotypes Associated with This Genotype
Genotype
MGI:3844643
Allelic
Composition		 Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Nfatc2*)Rao mutation (0 available); any Gt(ROSA)26Sor mutation (1083 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:148341 )
• hyperresponsive to stimulation
abnormal interferon level ( J:148341 )
• increased production of IFNG following low level stimulation

homeostasis/metabolism
abnormal interferon level ( J:148341 )
• increased production of IFNG following low level stimulation

hematopoietic system
abnormal T cell activation ( J:148341 )
• hyperresponsive to stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory