About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3844311
Allelic
Composition
Apctm1Tno/Apc+
Tg(CDX2-cre)101Erf/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (61 available)
Tg(CDX2-cre)101Erf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• a small number of mice also develop mammary tumors

integument
• a small number of mice also develop mammary tumors

mortality/aging
• 36% (13/36) animals survived to 300 days of observation; 3 died and 20 were euthanized upon signs of distress

growth/size/body
• males show inhibited weight gain after 120 days

neoplasm
• mice show around 10 tumors
• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine
• colorectal tumors may be observed at early time points
• male mice have about 60% more colon tumors than controls
• a small number of mice also develop mammary tumors

digestive/alimentary system
• greater than half the animals observed developed rectal prolapse with intermittent bleeding
• an average of 5-8 tumors are found in colon and rectum, wit some tumors being observed in the cecum and distal small intestine
• colorectal tumors may be observed at early time points
• male mice have about 60% more colon tumors than controls
• some (3) animals died during the observation period from intestinal obstruction by tumor

hematopoietic system
• mice exhibit mild anemia
• mice displaying mild anemia show hematocrits in range of 33 to 35% compared to around 45% in controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
colorectal cancer DOID:9256 OMIM:114500
J:126018


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory