Phenotypes Associated with This Genotype

Genotype
MGI:3844212

• Allelic Composition: Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

spleen hyperplasia ( J:131161 )

• spleen cellularity is increased by about 50% compared to controls

abnormal B cell differentiation ( J:131161 )

• B cell development is partially blocked at an early transition stage but not to the degree that Blnk null homozygotes are

• evidence includes a lower number of peripheral B cells, an increase percentage of B220⁺ IgL^- cells and a 10-fold increase in the number of marrow cells expressing pre-BCR

increased pro-B cell number ( J:131161 )

• there is an increase in B220⁺ IgL^- cells in the bone marrow

abnormal NK cell physiology ( J:187430 )

• NK cells exhibit partially reduced conjugation with RMA-S cells compared with wild-type cells

• decreased killing of hematopoietic cells RMA-S and YAC-1 cells

hematopoietic system

spleen hyperplasia ( J:131161 )

• spleen cellularity is increased by about 50% compared to controls

abnormal B cell differentiation ( J:131161 )

• B cell development is partially blocked at an early transition stage but not to the degree that Blnk null homozygotes are

• evidence includes a lower number of peripheral B cells, an increase percentage of B220⁺ IgL^- cells and a 10-fold increase in the number of marrow cells expressing pre-BCR

increased pro-B cell number ( J:131161 )

• there is an increase in B220⁺ IgL^- cells in the bone marrow

abnormal NK cell physiology ( J:187430 )

• NK cells exhibit partially reduced conjugation with RMA-S cells compared with wild-type cells

• decreased killing of hematopoietic cells RMA-S and YAC-1 cells

growth/size/body

spleen hyperplasia ( J:131161 )

• spleen cellularity is increased by about 50% compared to controls