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Phenotypes Associated with This Genotype
Genotype
MGI:3843982
Allelic
Composition		 Adartm1.1Phs/Adartm2Phs
Tg(Tal1-cre/ERT)42-056Jrg/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm1.1Phs mutation (3 available); any Adar mutation (83 available)
Adartm2Phs mutation (0 available); any Adar mutation (83 available)
Tg(Tal1-cre/ERT)42-056Jrg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased bone marrow cell number ( J:142338 )
• bone marrow cellularity is reduced in mice after cre induction
abnormal hematopoietic stem cell morphology ( J:142338 )
• the frequency of Lin- c-Kit+Sca-1- hematopoietic stem cells (HSC) in the bone marrow after cre induction is much lower than controls
• the frequency of Lin- c-Kit+Sca-1+ HSC in the bone marrow after cre induction is much higher than controls
• 68% of actively cycling HSCs are apoptotic after cre induction versus 3-13% in control mice
• the bone marrow has many fewer Lin- c-Kit+Sca-1+CD34lo HSC cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory