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Phenotypes Associated with This Genotype
Genotype
MGI:3843812
Allelic
Composition
Myf5tm3(cre)Sor/Myf5+
Ntf3tm2Jae/Ntf3tm2Jae
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Ntf3tm2Jae mutation (1 available); any Ntf3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show a flexed posture when inverted, similar to Erbb2 and Ntf3;Egr3 conditional mutants
• mice exhibit a wide-based, ataxic gait, similar to Erbb2 conditional mutants; onset of abnormalities is delayed and is less pronounced, however, relative to Erbb2 conditional animals

nervous system
• at P5, ventral root potentials are normal, but by P14, amplitudes of potentials are reduced by >75% compared to controls, similar to Ntf3;Egr3 conditional mutants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory