Phenotypes Associated with This Genotype

Genotype
MGI:3843773

• Allelic Composition: Tekt3^tm1Zuk/Tekt3^tm1Zuk
• Genetic Background: either: 129S7/SvEvBrd-Tekt3^tm1Zuk or (involves: 129S7/SvEvBrd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Structural defects in Tekt3^tm1Zuk/Tekt3^tm1Zuk spermatozoa flagella

reproductive system

reproductive system phenotype ( J:148050 )

N • despite abnormal sperm motility, male mice exhibit normal fertility

hairpin sperm flagellum ( J:148050 )

♂ • mutant sperm frequently exhibit flagellar bending (typically up to 180 degrees) at the annulus at the junction of the midpiece and the principal piece

asthenozoospermia ( J:148050 )

♂ • the percentage of motile spermatozoa is reduced compared to in wild-type mice

♂ • sperm exhibit defective flagellar beat pattern and lack of forward progression unlike wild-type sperm

cellular

hairpin sperm flagellum ( J:148050 )

♂ • mutant sperm frequently exhibit flagellar bending (typically up to 180 degrees) at the annulus at the junction of the midpiece and the principal piece

asthenozoospermia ( J:148050 )

♂ • the percentage of motile spermatozoa is reduced compared to in wild-type mice

♂ • sperm exhibit defective flagellar beat pattern and lack of forward progression unlike wild-type sperm