Phenotypes Associated with This Genotype

Genotype
MGI:3843771

• Allelic Composition: Foxb1^tm1Sli/Foxb1^tm1Sli
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:40032 )

• born in the expected frequency

• most die within 48 hours

• elevated mortality continues through two more weeks

• mice surviving perinatal period tend to have a normal life span and are fertile

growth/size/body

decreased body size ( J:40032 )

• never completely recover from early growth retardation

postnatal growth retardation ( J:40032 )

• normal weight and size at birth

• markedly reduced growth rate immediately after birth

• half normal weight by 7 days of age

• growth rate parallels that of controls after weaning

behavior/neurological

behavior/neurological phenotype ( J:40032 )

N • food consumption after weaning is normal

limb grasping ( J:40032 )

• abnormal clutching reflex

decreased grip strength ( J:40032 )

• some individual display a reduced ability to support their weight by grasping a rod

abnormal locomotor behavior ( J:40032 )

• move about more slowly than controls

abnormal gait ( J:40032 )

• broad based gait in some individuals

decreased locomotor activity ( J:40032 )

• reduced motor activity

• move about less in the cage