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Phenotypes Associated with This Genotype
Genotype
MGI:3843698
Allelic
Composition
Tg(Prnp-tTA)F959Sbp/0
Tg(tetO-Chrnb2*V287L)H3Gica/0
Genetic
Background
involves: 129S7/SvEvBrd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-tTA)F959Sbp mutation (1 available)
Tg(tetO-Chrnb2*V287L)H3Gica mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit seizures of 3 to 21 episodes during 24 hours each lasting 15 to 40 seconds
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• most seizures occur during the light period (resting-sleeping)
• however, doxycycline treatment between E1 and P15 prevents seizures
• mice display abnormal electroencephalogram with frequent spikes of high amplitudes unlike wild-type mice
• delta waves predominant unlike in wild-type mice where theta waves are more representatives
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• however, doxycycline treatment between E1 and P15 prevents high amplitude spikes and restores prevalence of theta waves

behavior/neurological
• mice exhibit seizures of 3 to 21 episodes during 24 hours each lasting 15 to 40 seconds
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• most seizures occur during the light period (resting-sleeping)
• however, doxycycline treatment between E1 and P15 prevents seizures

Mouse Models of Human Disease
OMIM ID Ref(s)
Epilepsy, Nocturnal Frontal Lobe, 3; ENFL3 605375 J:145855


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory