Mouse Genome Informatics
cx
    Tg(Prnp-tTA)F959Sbp/0
Tg(tetO-Chrnb2*V287L)H3Gica/0

involves: 129S7/SvEvBrd * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• mice exhibit seizures of 3 to 21 episodes during 24 hours each lasting 15 to 40 seconds
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• most seizures occur during the light period (resting-sleeping)
• however, doxycycline treatment between E1 and P15 prevents seizures
• mice display abnormal electroencephalogram with frequent spikes of high amplitudes unlike wild-type mice
• delta waves predominant unlike in wild-type mice where theta waves are more representatives
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• however, doxycycline treatment between E1 and P15 prevents high amplitude spikes and restores prevalence of theta waves

behavior/neurological
• mice exhibit seizures of 3 to 21 episodes during 24 hours each lasting 15 to 40 seconds
• seizures occur mainly during periods of increased delta activity regardless of doxycycline treatment as adults to silence the transgene
• most seizures occur during the light period (resting-sleeping)
• however, doxycycline treatment between E1 and P15 prevents seizures

Mouse Models of Human Disease
OMIM IDRef(s)
Epilepsy, Nocturnal Frontal Lobe, 3; ENFL3 605375 J:145855