Analysis Tools
behavior/neurological
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• mutant mice do not show an antinociceptive response to the hot plate test at any dose of nicotine, whereas control mice show a dose-dependent antinociceptive response
• in contrast, nicotine causes a reduced but not absent dose-dependent analgesia in the tail flick test in mutant mice
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nervous system
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• ipsilateral projections from the retina are more extended
• dense innervation of the superior colliculus and the stratum griseum superficiale
• distribution of contralateral projections from the retina is unaffected
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• contralateral retinogeniculate projections cover the entire dorsal lateral nucleus rather than just the caudo-dorsal distribution found in controls
• ipsilateral retinogeniculate projections remain in the dorso-medial region
• retinogeniculate projections remain intermixed at 9 days of age when projections are segregating in controls and at 30 days
• binocular visual cortex is extended about 39%
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• spontaneous firing rate of dorsal lateral geniculate nucleus cells is higher than in controls
• neurons are more visually responsive
• shorter latencies and better response at higher temporal frequencies
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• patch-clamp recordings indicate a loss of nicotine -elicited currents in serotonergic neurons in the raphe nucleus and thalamic neurons from mutant mice
• however, neurons in the superficial layers of the dorsal horn of the spinal cord continue to show a nicotine-elicited, dose-dependent augmentation of the frequency of post-synaptic currents
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vision/eye
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• visual acuity reduced by a factor of two
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immune system
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• decreased numbers in bone marrow but not in spleen
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hematopoietic system
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• decreased numbers in bone marrow but not in spleen
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