Phenotypes Associated with This Genotype

Genotype
MGI:3843184

• Allelic Composition: Rb1^tm1Tyj/Rb1^tm2Tyj
• Genetic Background: chimera involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

cachexia ( J:59268 )

• display severe wasting and become moribund by 3-4 months

neoplasm

increased pituitary adenoma incidence ( J:59268 )

• severe adenocarcenomas by 3-4 months of age in chimeric mice

• derived from the intermediate lobe

preneoplasia ( J:59268 )

• hyperchromatic cells are found in the adrenal medulla of chimeric mice indicating neoplastic lesions

nervous system

nervous system phenotype ( J:59268 )

N • examined in chimeric mice

increased pituitary adenoma incidence ( J:59268 )

• severe adenocarcenomas by 3-4 months of age in chimeric mice

• derived from the intermediate lobe

abnormal Purkinje cell morphology ( J:59268 )

• cells with enlarged nuclei

ectopic Purkinje cell ( J:59268 )

• displaced Purkinje cells

thin cerebellar granule layer ( J:59268 )

liver/biliary system

abnormal hepatocyte morphology ( J:59268 )

• abnormally large nuclei in chimeric mice

vision/eye

vision/eye phenotype ( J:59268 )

N • examined in chimeric mice

N • no retinoblastomas

N • normal retinal architecture

cataract ( J:59268 )

• in all mice examined

• evidence of cataracts when eyes first open at 1 week of age

• characterized by a posterior migration of the lens epithelium

• associated with bladder cell formation and sometimes with calcification

• lens of newborns highly disorganized with many pyknotic cells

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:59268 )

• severe adenocarcenomas by 3-4 months of age in chimeric mice

• derived from the intermediate lobe