Mouse Genome Informatics
hm
    Ihhtm1.1Dcha/Ihhtm1.1Dcha
either: (involves: 129S/SvEv * FVB/N) or (involves: 129S/SvEv * FVB/N * ICR)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
skeleton
• abnormal and shortened limb skeletal elements are visible by E13.5
• absent middle phalange on digit V
• severely shortened middle phalanges on digits II - IV
• decrease in the number of proliferating cells in the developing cartilage anlagen of the long bones at E15.5
• expression analysis indicates a delay in endochondral bone ossification at E14.5

limbs/digits/tail
• absent middle phalange on digit V
• severely shortened middle phalanges on digits II - IV
• marked decrease in the length of the most distal cartilage element before the last joint formation
• decrease in the recruitment of surrounding proliferating mesenchymal cells into the most distal cartilage element

Mouse Models of Human Disease
OMIM IDRef(s)
Brachydactyly, Type A1; BDA1 112500 J:147878