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Phenotypes Associated with This Genotype
Genotype
MGI:3842982
Allelic
Composition
Ihhtm1.1Dcha/Ihhtm1.1Dcha
Genetic
Background
either: (involves: 129S/SvEv * FVB/N) or (involves: 129S/SvEv * FVB/N * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1.1Dcha mutation (0 available); any Ihh mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• abnormal and shortened limb skeletal elements are visible by E13.5
• absent middle phalange on digit V
• severely shortened middle phalanges on digits II - IV
• decrease in the number of proliferating cells in the developing cartilage anlagen of the long bones at E15.5
• expression analysis indicates a delay in endochondral bone ossification at E14.5

limbs/digits/tail
• absent middle phalange on digit V
• severely shortened middle phalanges on digits II - IV
• marked decrease in the length of the most distal cartilage element before the last joint formation
• decrease in the recruitment of surrounding proliferating mesenchymal cells into the most distal cartilage element

Mouse Models of Human Disease
OMIM ID Ref(s)
Brachydactyly, Type A1; BDA1 112500 J:147878


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory