Phenotypes Associated with This Genotype

Genotype
MGI:3842677

• Allelic Composition: Cdkn2a^tm3(cre)Cjs/Cdkn2a^tm4Cjs
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:147752 )

• in one animal with monocular total blindness, lens of blind eye was significantly damaged as well as the retina, while lens and neuroretina of other eye were normal

• in an animal with partial bilateral vision loss, less severe accumulation of retrolental cells with focal attachment to the lens was observed with less severe deformation of the retina compared to animals exhibiting complete blindness

microphthalmia ( J:147752 )

• retina/lens lesions collectively contribute to gross anatomic micropthalmia in mutants

abnormal retina morphology ( J:147752 )

• typical lesions observed are aberrant retinal folding, appearance of dysplastic neuroretina detached from pigmented epithelium, and emergence of a fibrotic retrolental mass containing pigmented cells that erodes the posterior lens

• severity of anatomical defects correlates with functional impairment

retina fold ( J:147752 )

• aberrant retinal folding

blindness ( J:147752 )

• at 5 months of age, animals display varying ocular defects with some animals being totally blind or having partial bilateral vision impairment and some having normal vision;