Phenotypes Associated with This Genotype

Genotype
MGI:3842543

• Allelic Composition: Cd74^tm1Eae/Cd74^tm1Eae
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell proliferation ( J:113050 , J:132865 )

• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)

• following anti-CD74 stimulation (J:132865)

decreased CD4-positive, alpha-beta T cell number ( J:113050 )

decreased IgM level ( J:113050 )

• in response to NP immunization

abnormal level of surface class II molecules ( J:65917 )

• cell surface expression of class II molecules in splenocytes is decreased compared to in wild-type cells

cellular

decreased cell proliferation ( J:147772 )

• mouse embryonic fibroblasts transformed retrovirally with Ras produce fewer and smaller colonies than similarly treated wild-type cells

decreased B cell proliferation ( J:113050 , J:132865 )

• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)

• following anti-CD74 stimulation (J:132865)

hematopoietic system

decreased B cell proliferation ( J:113050 , J:132865 )

• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)

• following anti-CD74 stimulation (J:132865)

decreased CD4-positive, alpha-beta T cell number ( J:113050 )

decreased IgM level ( J:113050 )

• in response to NP immunization