Phenotypes Associated with This Genotype

Genotype
MGI:3842462

• Allelic Composition: Ache^tm4Pata/Ache^tm4Pata
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

infertility ( J:147425 )

• mice fail to reproduce

behavior/neurological

abnormal involuntary movement ( J:147425 )

• mice exhibit involuntary motor movement unlike wild-type mice

decreased grip strength ( J:147425 )

• decreased

abnormal posture ( J:147425 )

• mice exhibit flattened posture with limbs spread out unlike wild-type mice

hunched posture ( J:147425 )

abnormal vocalization ( J:147425 )

respiratory system

abnormal respiration ( J:147483 )

• inspiratory time is shorter than in wild-type mice

• ventilation relative to body size is mildy abnormal

decreased tidal volume ( J:147483 )

• tidal volume is increased in bambuterol-treated and untreated mice compared to similarly treated wild-type mice

increased tidal volume ( J:147483 )

• tidal volume is increased in bambuterol-treated and untreated mice compared to similarly treated wild-type mice

abnormal respiratory function ( J:147483 )

• mice exhibit increased inspiratory flow compared to in wild-type mice

increased pulmonary ventilation ( J:147483 )

• bambuterol-treated mice exhibit a rapid decrease in tidal volume compared to similarly treated wild-type mice

homeostasis/metabolism

decreased body temperature ( J:147483 )

• bambuterol-treated mice exhibit a slow decrease in body temperature compared to similarly treated wild-type mice

increased physiological sensitivity to xenobiotic ( J:147483 )

• bambuterol-treated mice exhibit a rapid decrease in tidal volume and a slow decrease in body temperature compared to similarly treated wild-type mice

growth/size/body

decreased body size ( J:147425 )

decreased body weight ( J:147425 , J:147483 )