Phenotypes Associated with This Genotype

Genotype
MGI:3842450

• Allelic Composition: Ache^tm4Pata/Ache^tm4Pata
• Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:147855 )

• weak grip

weakness ( J:147855 )

abnormal vocalization ( J:147855 )

• mice chirp whereas wild-type mice do not

impaired exercise endurance ( J:147855 )

• mice perform poorly on a treat mill compared to wild-type mice

seizures ( J:147855 )

• mice are seizure prone compared to wild-type mice

growth/size/body

decreased body size ( J:147855 )

homeostasis/metabolism

impaired exercise endurance ( J:147855 )

• mice perform poorly on a treat mill compared to wild-type mice

muscle

muscle weakness ( J:147855 )

• mice exhibit decreased muscle strength in a wire hang, cage top hang, grip, and pole test compared to wild-type mice

nervous system

seizures ( J:147855 )

• mice are seizure prone compared to wild-type mice

reproductive system

infertility ( J:147855 )

• mice fail to raise viable pups