Phenotypes Associated with This Genotype

Genotype
MGI:3842430

• Allelic Composition: Pou4f2^tm1Nat/Pou4f2^tm2.1Nat; Tg(Pax6-cre,GFP)2Pgr/?
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:147350 )

• retinal ganglion cells (RGC) have larger surface area and thick arbors

• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data

• a small percentage of RGC lack axons

• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL)

• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls

• these misplaced RGC display morphological characteristics of glycinergic amacrine cells

• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract

• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing

decreased retina ganglion cell number ( J:147350 )

• 70% of retinal ganglion cells are not present

nervous system

abnormal optic tract morphology ( J:147350 )

• large decrements in RGC projections occur to the nucleus adjacent to the optic tract compared to controls

• the accessory optic tract is missing

• numerous neurites emerge at P4 from the optic tract and penetrate nearby nontarget areas

abnormal superior colliculus morphology ( J:147350 )

• large decrements in RGC projections occur to this part of the brain compared to controls

abnormal lateral geniculate nucleus morphology ( J:147350 )

• large decrements in RGC projections occur to this part of the brain compared to controls

abnormal retina ganglion cell morphology ( J:147350 )

• retinal ganglion cells (RGC) have larger surface area and thick arbors

• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data

• a small percentage of RGC lack axons

• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL)

• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls

• these misplaced RGC display morphological characteristics of glycinergic amacrine cells

• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract

• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing

decreased retina ganglion cell number ( J:147350 )

• 70% of retinal ganglion cells are not present