Phenotypes for Gusb Kit MGI:3842194 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gusb^mps/Gusb^mps Kit^W-41J/Kit^W-41J
Genetic Background	B6(C)-Kit^W-41J Gusb^mps/BrkJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gusb^mps mutation (8 available); any Gusb mutation (45 available)
Kit^W-41J mutation (5 available); any Kit mutation (175 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:58272 )

• average life span is approximately 26 weeks

hematopoietic system

decreased hematopoietic stem cell number ( J:58272 )

• severe deficiency of hematopoietic stem cells

cellular

abnormal lysosome morphology ( J:58272 )

• extensive lysosomal storage, evident histologically as large cleared foamy cells, in the liver, kidney, and spleen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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