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Phenotypes Associated with This Genotype
Genotype
MGI:3842142
Allelic
Composition		 Smotm1Amc/Smotm1Amc
Tulp3hhkr/Tulp3hhkr
Genetic
Background		 involves: 129X1/SvJ * C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm1Amc mutation (1 available); any Smo mutation (44 available)
Tulp3hhkr mutation (1 available); any Tulp3 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:147584 )
• expression of neural tube markers is ventralized compared to in wild-type mice
increased spinal cord size ( J:147584 )
• mice exhibit an expansion of the caudal spinal cord unlike in wild-type mice

cardiovascular system

homeostasis/metabolism

embryo
abnormal neural tube morphology ( J:147584 )
• expression of neural tube markers is ventralized compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory