Phenotypes for Shh Tulp3 MGI:3842141 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Shh^tm1Chg/Shh^tm1Chg Tulp3^hhkr/Tulp3^hhkr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)
Tulp3^hhkr mutation (1 available); any Tulp3 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:147584 )

• expression of neural tube markers is ventralized compared to in wild-type mice

spina bifida ( J:147584 )

exencephaly ( J:147584 )

limbs/digits/tail

oligodactyly ( J:147584 )

• mice exhibit two digits on fore limbs and four digits on the hind limbs unlike in wild-type mice

homeostasis/metabolism

edema ( J:147584 )

embryo

abnormal neural tube morphology ( J:147584 )

• expression of neural tube markers is ventralized compared to in wild-type mice

spina bifida ( J:147584 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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