Phenotypes Associated with This Genotype

Genotype
MGI:3841991

• Allelic Composition: Hba^th-J/Hba^th-J
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:29665 )

• no homozygous embryos can be detected by E6.5, the percentage of homozygotes in heterozygous intercross matings is reduced to only 7.7% rather than the expected 25% by E5.5, but homozygotes implant and are found at normal numbers at implantation

• degeneration of homozygous embryos begins on E5.5 and is complete by E6.5

embryo

abnormal blastocyst morphology ( J:29665 )

• homozygous blastocysts have fewer trophectoderm cells, 78.6% of normal, and slightly fewer than normal cells of the inner cell mass and therefore have fewer total cells than normal

abnormal inner cell mass morphology ( J:29665 )

• cells of the inner cell mass of homozygous blastocysts hatched from the zona pellucida and grown in culture become necrotic and and do not remain associated with the trophoblast monolayer, as happens in wildtype blastocyst cultures

abnormal trophectoderm morphology ( J:29665 )