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Phenotypes Associated with This Genotype
Genotype
MGI:3841959
Allelic
Composition
Cyp11b1tm1Chjk/Cyp11b1tm1Chjk
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp11b1tm1Chjk mutation (0 available); any Cyp11b1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cyp11b1tm1Chjk/Cyp11b1tm1Chjk mice display adrenal hypertrophy

reproductive system
• the uteri are enlarged with multiple cysts unlike in wild-type mice
• female mice are infertile despite normally cycling in young females and the ability of older mice to ovulate when treated with pregnant mare serum and human chorionic gonadotrophin

homeostasis/metabolism
• following handling, mice fail to exhibit an increase in plasma corticosterone levels unlike wild-type mice
• in males, but not female, mice
• in males, but not female, mice
• urine contains decreased aldosterone levels compared to in wild-type mice
• mice exhibit a decrease in corticosterone (9.5-fold and 18-fold in male and female mice, respectively) urine content compared to in wild-type mice
• urine contains increased progesterone levels compared to in wild-type mice
• mice exhibit an increase in deoxycorticosterone (27- and 44-fold in males and females, respectively) urine content compared to in wild-type mice

endocrine/exocrine glands
• wider than normal due to cell hypertrophy
• mice exhibit increased adrenal gland size compared to in wild-type mice with female mice exhibiting less hypertrophy than male mice
• mice exhibit increased adrenal gland size compared to in wild-type mice with female mice exhibiting less hypertrophy than male mice
• pituitary glands are hypertrophied with an increased in the numbers of corticotropes compared to in wild-type mice
• in males, but not female, mice

nervous system
• pituitary glands are hypertrophied with an increased in the numbers of corticotropes compared to in wild-type mice

cardiovascular system

renal/urinary system
• urine contains decreased aldosterone levels compared to in wild-type mice
• mice exhibit a decrease in corticosterone (9.5-fold and 18-fold in male and female mice, respectively) urine content compared to in wild-type mice
• urine contains increased progesterone levels compared to in wild-type mice
• mice exhibit an increase in deoxycorticosterone (27- and 44-fold in males and females, respectively) urine content compared to in wild-type mice
• in males, but not female, mice

adipose tissue
• mice exhibit a decrease in mesenteric, gonadal, subcutaneous, and brown adipose compared to in wild-type mice

hematopoietic system
• in males, but not female, mice

liver/biliary system

immune system
• in males, but not female, mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory