Phenotypes Associated with This Genotype

Genotype
MGI:3841482

• Allelic Composition: Tert^tm1Leah/Tert⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

aneuploidy ( J:90866 )

• late passages of heterozygous mutant ES cells display increased aneuploidy relative to wild-type ES cells

abnormal telomere length ( J:90866 )

• late passages (P25 and P50) but not early passages (P1) of heterozygous mutant ES cells show a modest reduction in telomeric restriction fragment (TRF) length by pulsed-field gel electrophoresis; not observed in early or late passages of wild-type ES cells

• P50 but not P1 heterozygous mutant ES cells show decreased telomere signal intensity at some chromosome ends, as shown by FISH analysis on metaphase spreads

• however, no end-to-end chromosomal fusions are detected in P50 heterozygous mutant ES cells, despite the presence of shortened telomeres