Analysis Tools
immune system
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• decreased T cell proliferation when stimulated by CD3 cross linking but not when stimulated by PMA or ionomycin
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• swelling of ankles and forepaws induced by injection of serum from mice transgenic for Tg(TcraR28,TcrbR28)KRNDim is significantly reduced compared to controls
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behavior/neurological
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• no abnormalities in motor activity or anxiety like behavior are detected
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• when using a modest training protocol mice display significantly less freezing upon reexposure 24 hours later to the context or cue but no defect is detected when reexposure occurs 1 hour after training suggesting an impairment in long term memory
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• when using a modest training protocol mice display significantly less freezing upon reexposure 24 hours later to the context
• however, no defect is detected when a more intense training protocol is used or when testing is done 1 hour after training
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• when using a modest training protocol mice display significantly less freezing upon reexposure 24 hours later to the cue
• however, no defect is detected when a more intense training protocol is used or when testing is done 1 hour after training
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• in a probe trial of a Morris water maze 7 days after training mice display fewer platform crossings but spend a similar amount of time in the target quadrant compared to controls
• 24 hours after training latency to enter the dark side (where a shock was given during training) is reduced compared to controls
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nervous system
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• cell body spiking following the first train of theta burst is significantly reduced compared to controls
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• decrease in theta burst stimulated long term potentiation, especially in the first hour post induction
• however, long term potentiation in response to 2 high frequency stimulations is similar to controls
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hematopoietic system
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• decreased T cell proliferation when stimulated by CD3 cross linking but not when stimulated by PMA or ionomycin
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skeleton
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• swelling of ankles and forepaws induced by injection of serum from mice transgenic for Tg(TcraR28,TcrbR28)KRNDim is significantly reduced compared to controls
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cellular
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• decreased T cell proliferation when stimulated by CD3 cross linking but not when stimulated by PMA or ionomycin
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