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Phenotypes Associated with This Genotype
Genotype
MGI:3841388
Allelic
Composition		 Mplhlb219/Mpl+
Genetic
Background		 C57BL/6J-Mplhlb219/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mplhlb219 mutation (2 available); any Mpl mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:146577 )
• mutant mice exhibit a significant increase in the progenitor CFU-GM, CFU-M, and CFU-Mk populations compared to controls
decreased erythrocyte cell number ( J:146577 )
• significantly fewer red blood cells compared to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory