Phenotypes Associated with This Genotype

Genotype
MGI:3841387

• Allelic Composition: Bptf^Gt(XG023)Byg/Bptf^Gt(XG023)Byg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:147414 )

• embryonic lethality occurs between E7.5 and E8.5

embryo

abnormal rostral-caudal axis patterning ( J:147414 )

• absence of a primitive streak and any discernable mesoderm suggests that the anterior-posterior axis does not form in E7.5 embryos

embryonic growth arrest ( J:147414 )

• growth of embryonic and extra-embryonic tissues between E5.5 and E7.5 is slow and has defects

• a lack of visceral endoderm suggests embryos arrest development prior to E5.5

absent mesoderm ( J:147414 )

• mesoderm does not form by E7.5

failure of primitive streak formation ( J:147414 )

• a primitive streak does not form by E6.5

absent anterior visceral endoderm ( J:147414 )

• the anterior visceral endoderm fails to form in E5.5 embryos

absent distal visceral endoderm ( J:147414 )

• the distal visceral endoderm fails to form in E5.5 embryos

cellular

decreased cell proliferation ( J:147414 )

• at E5.5, E6.5 and E7.5, levels of phosphorylated histone-3 are reduced by 40-50% indicating a decrease in cellular proliferation