Phenotypes Associated with This Genotype

Genotype
MGI:3841211

• Allelic Composition: Adipoq^tm1Chan/Adipoq⁺
• Genetic Background: B6.129-Adipoq^tm1Chan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased leukocyte cell number ( J:122020 )

• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in wild type mice

• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

cellular

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

cardiovascular system

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

homeostasis/metabolism

decreased circulating adiponectin level ( J:122020 )

• 58% reduction in total plasma adiponectin levels compared with wild-type mice

hematopoietic system

increased leukocyte cell number ( J:122020 )

• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in wild type mice

• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin