Phenotypes Associated with This Genotype

Genotype
MGI:3841067

• Allelic Composition: F10^tm2Ccmt/F10^tm2Ccmt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:145092 )

N • unlike mice homozygous for F10 null alleles, survival for the first month of life is 100% and 80% at 18 months

cardiovascular system

increased heart iron level ( J:145092 )

• at 10 months, mice exhibit iron depositions in the myocardium accompanied by fibrosis unlike in wild-type mice

cardiac fibrosis ( J:145092 )

• at 10 months, mice exhibit fibrosis that accompanies iron deposits unlike wild-type mice

homeostasis/metabolism

increased heart iron level ( J:145092 )

• at 10 months, mice exhibit iron depositions in the myocardium accompanied by fibrosis unlike in wild-type mice