Phenotypes Associated with This Genotype

Genotype
MGI:3841057

• Allelic Composition: Pax2^1Neu/Pax2⁺
• Genetic Background: involves: 102

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:89465 )

increased pancreatic islet number ( J:89465 )

pancreatic islet hyperplasia ( J:89465 )

• the volume islet cells occupy in the pancreas is increased 2-fold compared to in wild-type mice

• islet cell size is increased 1.4-fold compared to in wild-type mice

renal/urinary system

increased kidney apoptosis ( J:136502 )

• cisplatin-exposed kidney explants exhibit a 50% increase in apoptosis compared to wild-type cells

cellular

increased kidney apoptosis ( J:136502 )

• cisplatin-exposed kidney explants exhibit a 50% increase in apoptosis compared to wild-type cells