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Phenotypes Associated with This Genotype
Genotype
MGI:3840971
Allelic
Composition		 Foxo1tm1Flv/Foxo1tm1Flv
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-Il7r)1Asin/?
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (2 available); any Foxo1 mutation (31 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Tg(CD2-Il7r)1Asin mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:147057 )
• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells

hematopoietic system
decreased T cell number ( J:147057 )
• the Il7r transgene rescues the low T cell numbers observed in mice with Foxo1-deficient OT-II T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory