Phenotypes Associated with This Genotype

Genotype
MGI:3840966

• Allelic Composition: Tg(Prrx1-Sox9,-lacZ)1Haak/Tg(Prrx1-Sox9,-lacZ)1Haak
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:121946 )

• deformed limbs at birth

abnormal limb bud morphology ( J:121946 )

• at E13.5, increased cell density is seen in the anterior and posterior limb bud mesenchyme corresponding to areas of transgene expression and cell proliferation in the posterior mesechyme is increased

• at E14.5 these excess cells aggregate and for an extra postaxial nubbin

abnormal digit morphology ( J:121946 )

• short and broad digits 1 and 5 on the fore and hind limbs

brachydactyly ( J:121946 )

• short and broad digits 1 and 5 on the fore and hind limbs

polydactyly ( J:121946 )

• a post axial nubbin is present on the hindlimbs

• skeletal preparations show pre and post axial polydactyly

abnormal forelimb morphology ( J:121946 )

• after 2 weeks of age mice walk with the backside of their forelimbs facing down towards the ground

short limbs ( J:121946 )

• very short limbs at birth

skeleton

abnormal cartilage development ( J:121946 )

• the chondrogenic mesenchymal condensation of the ulna is larger resulting in formation of a short but large cartilage primordia of the ulna

delayed endochondral bone ossification ( J:121946 )

• delayed endochondral bone formation is seen in the humerus, ulna, radius, and digits 1 and 5 at birth

embryo

abnormal limb bud morphology ( J:121946 )

• at E13.5, increased cell density is seen in the anterior and posterior limb bud mesenchyme corresponding to areas of transgene expression and cell proliferation in the posterior mesechyme is increased

• at E14.5 these excess cells aggregate and for an extra postaxial nubbin