Phenotypes Associated with This Genotype

Genotype
MGI:3840890

• Allelic Composition: In(2Hoxd11;Itga6)1Ddu/In(2Hoxd11;Itga6)1Ddu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Axial skeleton abnormalities in heterozygous and homozygous In(2Hoxd11;Itga6)1Ddu mice

skeleton

sternebra fusion ( J:146752 )

• sternebrae 4 and 5 are fused

abnormal sternocostal joint morphology ( J:146752 )

• mice exhibit a misalignment of the first rib to the sternum

abnormal cervical vertebrae morphology ( J:146752 )

• C7 exhibits protrusion of ectopic bony material from the transverse process unlike in wild-type mice

increased lumbar vertebrae number ( J:146752 )

• 7 of 9 mice have a seventh lumbar vertebrae

sacral vertebral transformation ( J:146752 )

• 7 of 9 mice exhibit S1 to L7 transformation