Phenotypes Associated with This Genotype

Genotype
MGI:3840672

• Allelic Composition: \Oprm1^tm1Yxp/\Oprm1^tm1Yxp
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased chemically-elicited antinociception ( J:147079 )

• in radiant heat tail flick and hot plate assays the effective dose to see a response in 50% of mice (ED50) is significantly increased for heroin, morphine-6beta-glucuronide (M6G), and fentanyl

• however, the ED50 for morphine and methadone are not significantly different from controls

digestive/alimentary system

abnormal intestinal transit time ( J:147079 )

• exposure to M6G does not increase gastrointestinal transit time unlike in controls

• however, exposure to morphine increases gastrointestinal transit time in both mutants and controls