Phenotypes Associated with This Genotype

Genotype
MGI:3840353

• Allelic Composition: E2f1^tm1Njd/E2f1^tm1Njd; Rb1^tm1Tyj/Rb1⁺
• Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:47108 )

• increased survival relative to Rb1^tm1Tyj heterozygotes, 15.2 months on a 129 background and up to 17 months on a mixed background

neoplasm

increased pituitary gland tumor incidence ( J:47108 )

• only about 62% develop pituitary tumors

• pituitary tumors are smaller than Rb1^tm1Tyj heterozygotes but histologically indistinguishable

increased thyroid adenoma incidence ( J:47108 )

• fewer thyroid C-cell adenomas than in Rb1^tm1Tyj heterozygotes

increased hemangioma incidence ( J:47108 )

endocrine/exocrine glands

adrenal medulla hyperplasia ( J:47108 )

increased pituitary gland tumor incidence ( J:47108 )

• only about 62% develop pituitary tumors

• pituitary tumors are smaller than Rb1^tm1Tyj heterozygotes but histologically indistinguishable

abnormal thyroid gland morphology ( J:47108 )

• thyroid gland degeneration after 14 months of age

increased thyroid adenoma incidence ( J:47108 )

• fewer thyroid C-cell adenomas than in Rb1^tm1Tyj heterozygotes

reproductive system

uterine hemorrhage ( J:47108 )

♀

cardiovascular system

uterine hemorrhage ( J:47108 )

♀

nervous system

increased pituitary gland tumor incidence ( J:47108 )

• only about 62% develop pituitary tumors

• pituitary tumors are smaller than Rb1^tm1Tyj heterozygotes but histologically indistinguishable