About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3840352
Allelic
Composition		 E2f1tm1Njd/E2f1+
Rb1tm1Tyj/Rb1+
Genetic
Background		 either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Njd mutation (1 available); any E2f1 mutation (28 available)
Rb1tm1Tyj mutation (5 available); any Rb1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47108 )
• increased survival relative to Rb1tm1Tyj heterozygotes, 11.6 months on a 129 background and up to 12.6 months on a mixed background

neoplasm
increased tumor incidence ( J:47108 )
• develop grossly detectable pituitary tumors
increased thyroid adenoma incidence ( J:47108 )
• fewer thyroid C-cell adenomas than in Rb1tm1Tyj heterozygotes

endocrine/exocrine glands
increased thyroid adenoma incidence ( J:47108 )
• fewer thyroid C-cell adenomas than in Rb1tm1Tyj heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory