Phenotypes Associated with This Genotype

Genotype
MGI:3840210

• Allelic Composition: Tg(Lck-Bcl2l1)1Cant/?
• Genetic Background: B6.Cg-Tg(Lck-Bcl2l1)1Cant

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell proliferation ( J:77507 )

• proliferative and IL-2 responses of T cells after CD3, but not CD28, ligation are 3-4 fold greater than in T cells from controls

increased memory T cell number ( J:77507 )

• levels of memory T cells, based on CD62L and CD44 expression, are increased by about 50%

immune system

increased T cell proliferation ( J:77507 )

• proliferative and IL-2 responses of T cells after CD3, but not CD28, ligation are 3-4 fold greater than in T cells from controls

increased memory T cell number ( J:77507 )

• levels of memory T cells, based on CD62L and CD44 expression, are increased by about 50%

increased interleukin-2 secretion ( J:77507 )

• T cells display increased IL-2 production in response to CD3 ligation

cellular

increased T cell proliferation ( J:77507 )

• proliferative and IL-2 responses of T cells after CD3, but not CD28, ligation are 3-4 fold greater than in T cells from controls